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Endocrine Abstracts

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ea0029p1476 | Pituitary Clinical | ICEECE2012

Comparison of immunoassay and mass spectrometry measurement of cortisol during ACTH1--24 stimulation tests

Burt M , Mangelsdorf B , Whiting M , Rogers A , Ho J , Inder W , Doogue M

Measurement of plasma cortisol by immunoassay after ACTH1–24 stimulation is used to assess the hypothalamic–pituitary–adrenal (HPA) axis. Liquid chromatography–tandem mass spectrometry (LC–MS/MS) has greater specificity and equilibrium dialysis allows measurement of free plasma cortisol. We investigated whether measuring cortisol by LC–MS/MS improves the sensitivity of ACTH1–24 stimulation testing in pituitary patients. ...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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